Ultima-Follistion 344 1mg

MANUFACTURER Ultima Pharmaceuticals - USA
WAREHOUSE USA Warehouse 5
SUBSTANCE Follistatin

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Follistatin is a vital single-chain gonadal protein that plays a key role in regulating the release of follicle-stimulating hormone (FSH). This essential protein is encoded by the FST gene, which produces two distinct isoforms?FST317 and FST344?comprising 317 and 344 amino acids, respectively, due to the alternative splicing of its precursor mRNA. Follistatin acts as a direct antagonist to activin, effectively inhibiting the production and secretion of pituitary FSH.

Extensive research is being conducted on follistatin?s role in muscle growth regulation, particularly in mice, where it functions as an antagonist to myostatin (GDF-8), a member of the TGF superfamily that limits muscle development. Notably, studies by Lee & McPherron demonstrated that the genetic elimination of GDF-8 (through knockout mice) or an increase in follistatin levels resulted in significant muscle mass enhancement. Additional research from 2009 involving macaque monkeys indicated that gene therapy aimed at regulating follistatin also promoted muscle growth and improved strength.