Duphaston

CLASSIFICATION Progesterone Agonist
DOSAGE 10-30 mg/day
ACNE No
WATER RETENTION No
HBR Possibly
HEPATOTOXICITY Yes
AROMATIZATION No
MANUFACTURER Abbott
WAREHOUSE International Warehouse 2
SUBSTANCE Dydrogesterone

Duphaston is a specialized medication featuring dydrogesterone as its active ingredient. As a progesterone agonist, this female hormone therapy is primarily used to mitigate the risk of endometrial hyperplasia.

Doctors often prescribe Duphaston for various conditions, including:

• Irregular menstrual cycles
• Dysmenorrhea (painful menstruation)
• Endometriosis
• Infertility

When combined with estrogen, Duphaston can also effectively treat secondary amenorrhea (absence of menstrual periods for six months or more) and manage heavy or irregular bleeding.

It?s essential to avoid Duphaston in certain situations:

• Individuals with allergies to dydrogesterone or similar medications. If you notice allergy symptoms like:
• skin rash,
• itchiness,
• redness,
• swelling, or difficulty breathing, seek immediate medical assistance.
• Those diagnosed with deep vein thrombosis (a blood vessel blockage).
• Patients with cancers that rely on progesterone or estrogen.
• Individuals experiencing unexplained bleeding.
• Patients with liver dysfunction, as this medication may pose liver risks. Contact your healthcare provider if you experience:
• pain in the upper right abdomen,
• loss of appetite,
• dark urine, or
• jaundice (yellowing of skin and eyes).
• People with a history of depression.
• Patients diagnosed with porphyria.

Regular breast self-exams are recommended while taking this medication due to an increased risk of breast cancer when combined with estrogen.

Duphaston should only be used during pregnancy if prescribed by a healthcare professional. This medication can pass into breast milk, so breastfeeding is not advised while on Duphaston.

Your doctor will determine your specific dosage. Never self-medicate. Take the tablet whole with a glass of water; do not crush or chew.

It?s crucial to avoid Duphaston alongside the following medications:

• Antiepileptic drugs, including:
• carbamazepine,
• phenytoin,
• phenobarbital, and others, as they may lower Duphaston levels and effectiveness.
• HIV medications, such as:
• ritonavir,
• indinavir,
• saquinavir, and more.
• Herbal products like St. John's wort, sage, and ginkgo biloba, which can also reduce Duphaston efficacy.

Always inform your doctor about all medications and herbal supplements you are currently taking.

Potential side effects of Duphaston may include:

• Nausea
• Vomiting
• Headaches
• Dizziness
• Weight gain
• Breast swelling
• Anemia
• Depression
• Fatigue
• Liver damage (loss of appetite, right upper abdominal pain, jaundice)
• Allergic reactions, among others.

If you experience any side effects, promptly notify your healthcare provider.